Apply now »

We are experiencing a technical issue with the Careers Website. At the moment, applications are not possible. We are working on resolving the issue as soon as possible. Thank you for your patience.

Downstream Engineer III

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences.

We celebrate all dimensions of diversity. We believe that it drives excellence, innovation, and human progress. We care about our customers, patients, and our rich mix of people. This diversity strengthens our ability to lead in science and technology.

We are committed to creating access and opportunities for all and empower you to fulfil your ambitions. Our diverse businesses offer various career moves to seek new horizons.

Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to bring their curiosity to life!


Curious? Chat with one of our curious minds on our interactive Q&A platform and catch a glimpse of our people, values, and culture.  You can also apply and find more information at

If you would like to know more about what diversity, equity, and inclusion means to us, please visit


If you are a resident of a Connecticut or Colorado, you are eligible to receive additional information about the compensation and benefits, which we will provide upon request. You may contact 855 444 5678 from 8:00am to 5:30pm ET Monday through Friday, for assistance.

Your Role

We are seeking an experienced and highly motivated Engineer to join the company as a Downstream Engineer III, a critical role within the BioContinuum™ Platform Applications & Innovation team. This team is working at bench-scale, leading the evolution and convergence of process, analytical, and digital technologies to pioneer a facility of the future for continuous biomanufacturing. As an integral team member, you will drive the development of intensified processes through the design and execution of lab- and pilot-based experimental work in the areas of advanced downstream processing, including connection of downstream purification trains to perfusion production processes, continuous chromatography and filtration operations, and advanced control methods utilizing next generation sensors.

You will help shape our downstream strategy in intensified and continuous biomanufacturing by leveraging your industrial experience and understanding of manufacturing pain points and bottlenecks to propose new project concepts, to align objectives and project plans with key stakeholders, and to execute on project plans. Finally, you will disseminate key experimental results by supporting internal and external thought leadership activities.



Who You Are:


Minimum Qualifications:

  • Bachelor’s Degree in Chemical or Biochemical Engineering with 5+ years of biotech experience; or Master’s Degree in Chemical or Biochemical Engineering with 3+ years of biotech experience; or PhD in Chemical Engineering or Biochemical Engineering.
  • 1+ year experience applying chromatography theory to the hands-on development and optimization of protein purification processes via chromatographic separations



Preferred Qualifications:

  • Strong background and practical hands-on experience with purification and product quality analytical techniques, particularly for CHO cell-based processes and monoclonal antibodies
  • Experience operating small and large-scale protein purification systems, including clarification, chromatography, filtration, and other unit operations, including the development of automation and control strategies
  • Experience in statistical design of experiments (DoE) coupled with strong analytical and problem-solving skills; ability to solve problems creatively and contribute to innovation in product and process development
  • Ability to manage multiple projects simultaneously to meet project deliverables and timelines
  • Excellent verbal and written communication skills, ability to present at internal and external meetings and produce publication-quality documentation
  • Proven track record as a committed team player with the ability to work on multi-disciplinary teams in a matrix environment
  • Experience with continuous bioprocessing operations 
  • Experience with lab-based automation and data processing software such as LabView and MATLAB is a plus
  • Experience with on-line/at-line analytics (ie spectroscopy, HPLC, automated sampling) is a plus
  • Working knowledge of pharmaceutical/biotechnology regulatory and quality issues including GMP regulations and QbD principles is a plus

The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law.  This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.


As an employee of the Company, you will be required to comply with all of the Company’s COVID-19 safety protocols and policies. The organization has currently suspended enforcement of its COVID-19 Vaccination Policy, but that policy may be reinstated by the Company in its discretion.

Job Requisition ID:  246206
Location:  Bedford
Career Level:  D - Professional (4-9 years)
Working time model:  full-time

North America Disclosure
The Company is committed to accessibility in its workplaces, including during the job application process. Applicants who may require accommodation during the application process should speak with our Candidate Services team at 844-655-6466 from 8:00am to 5:30pm ET Monday through Friday. If you are a resident of a Connecticut or Colorado, you are eligible to receive additional information about the compensation and benefits, which we will provide upon request.  You may contact 855 444 5678 from 8:00am to 5:30pm ET Monday through Friday, for assistance.

Notice on Fraudulent Job Offers
Unfortunately, we are aware of third parties that pretend to represent our company offering unauthorized employment opportunities. If you think a fraudulent source is offering you a job, please have a look at the following information.

Nearest Major Market: Boston

Job Segment: R&D, Developer, Pharmaceutical, Biology, Biotech, Research, Technology, Science

Apply now »