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Associate Scientists

Job Title: Associate Scientists

 

Job Location: EMD SRDI, 45A Middlesex Turnpike, Billerica, Massachusetts, 01821

 

This position qualifies for EMD SRDI’s employee referral program.

 

Responsibilities:

 

The individual will work collaboratively with a group of scientists to develop and conduct in vitro cell-based assays to further our understanding of human autoimmune diseases and evaluate potential drug candidates.

Particular Job Duties:

  1. Develop and conduct cell-based assays using human primary immune cells or cell lines to support target validation and drug discovery efforts;

 

  1. Conduct translational biomarker studies using samples from patients with autoimmune diseases to support pharmacodynamics and target engagement biomarker discovery;

 

  1. Develop complex primary cell co-culture assays to support mechanism of action studies and/or drug candidate screening;

 

  1. Conduct gene expression or protein analysis;

 

  1. Prepare data reports to lab head and give presentations at internal and external meetings;

 

  1. Operate state of the art laboratory equipment such as Flow Cytometer, Luminex, MSD/EnVision plate reader and QPCR based expression platforms, as needed;

 

  1. Independently analyze and interpret data and troubleshoot experiments;

 

  1. Record data accurately in Electronic Laboratory Notebook and maintain records per company policy and legal requirements. Prepare study protocols and reports per request;

 

  1. Provide technical support to colleagues in own area of expertise when necessary; and

 

  1. Closely work with members in Cellular and Translational Immunology group to support departmental goals.

 

Requirements and Qualifications:

 

Education Requirements:

 

The Employer requires a Bachelor’s degree in Chemistry, Biochemistry or a closely related field and five years of progressively more responsible work experience culturing various cell lines, including complex primary cells.

 

Additionally, the successful candidate must have:

 

  1. Demonstrated knowledge of cell culture including primary patient-derived cell line and cell-based assay development (96-384 micro plate based) gained through five years of experience;

 

  1. Demonstrated knowledge of cellular assays such as cell viability, clonogenic, soft agar colony formation and proliferation assays gained through five years of work experience;

 

  1. Demonstrated knowledge of molecular biology techniques such as RT-PCR, western blot, immunoprecipitation and DNA/RNA/protein isolation gained through five years of work experience;

 

  1. Demonstrated knowledge of target validation, biomarker and drug discovery research gained through five years of work experience;

 

  1. Demonstrated knowledge of Graphpad Prism, maintaining laboratory notebooks and preparing research protocols gained through five years of work experience;

 

  1. Demonstrated knowledge of lentiviral vector construction, plasmid purification, cloning, transduction, transfection, tittering of shRNA vectors, lentiviral-based knockdown and overexpression gained through 2 years of experience; and

 

  1. Demonstrated knowledge of bioanalytical assays including view RNA ISH, staining on cells/ tissue section, ELISA, Luminex and MSD gained through one year of work experience.

 

All years of work experience may be gained concurrently.

 

Please send resumes to EMD SRDI, 400 Summit Drive, Burlington, MA 01803 (Attn: Req. #  210346

Job Requisition ID:  210346
Location:  Billerica
Career Level:  D - Professional (4-9 years)
Working time model:  full-time

Careers during Covid-19
Thank you for visiting our careers website, we are always looking for curious minds to join our teams. We understand how much the world is being impacted by the Covid-19 crisis and we want to assure you that your safety is very important to us. To ensure that everyone’s health is protected, instead of a standard face-to-face interview, it is likely that you will be offered alternative digital interview options.

US Disclosure
The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law.  This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

North America Disclosure
The Company is committed to accessibility in its workplaces, including during the job application process. Applicants who may require accommodation during the application process should speak with our HR Services team at 855 444 5678 from 8:00am to 5:30pm ET Monday through Friday.

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