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Principal Scientist, Medicinal Chemistry

Your role:

The Principal Scientist will contribute to the achievement of drug discovery project goals through the synthesis of target molecules by applying modern organic synthetic methods and following best medicinal chemistry practices and will:


  • Serve as target chemist and coordinate/prioritize the work of several internal or external (CRO) scientists working on the same project
  • Generate ideas for new molecules based on SAR/SPR analysis, structural information, HTS, fragment screening results, literature reports or other information.  Prioritize ideas, devise compound optimization strategies, form/test hypotheses for compound property improvements
  • Independently develop and execute routes for the synthesis of target molecules, as well as troubleshoot reactions and multistep reaction sequences
  • Be expert in mining chemical and other scientific literature
  • Propose and explore alternative synthetic routes, and synthetic strategies
  • Maintain close collaboration with fellow chemists and scientists from other disciplines in a team environment that is focused on achieving success towards common goals
  • Prepare and deliver reports, internal and external presentations in timely manner
  • Ensure that the company's intellectual property is fully protected by keeping detailed experimental details in laboratory notebooks according to company policy
  • Keep supervisor informed of progress and activities. Participates actively in department meetings, project meetings
  • Follow safe laboratory practices and complies with EHS, safety officers, and delegates to ensure that the laboratory is a safe environment. Recognizes potential safety issues, discusses them with EHS and management, and takes action to rectify them
  • Assume responsibility for certain pieces of laboratory equipment, ensures that they are properly maintained and serviced, and facilitates their use by other scientists


Who you are:

  • Bachelor’s degree with 8 plus years of experience, master’s degree with 3 plus years of experience, or PhD degree in Organic Chemistry or related science
  • 5 plus years of related post-degree experience in Pharmaceutical/Biotech industry preferred
  • Must have proven scientific expertise in Organic synthesis and Medicinal chemistry
  • Publication record in peer reviewed journals
  • Self-driven, self-motivated, with scientific curiosity
  • Excellent oral and written communication skills
  • Strong team spirit and good interpersonal skills
  • Adaptability, flexibility
Job Requisition ID:  189673
Location:  Billerica
Career Level:  E - Professional (10+ years)
Working time model:  full-time

US Disclosure
The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law.  This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

North America Disclosure
The Company is committed to accessibility in its workplaces, including during the job application process. Applicants who may require accommodation during the application process should speak with our HR Services team at 855 444 5678 from 8:00am to 5:30pm ET Monday through Friday.

Nearest Major Market: Boston

Job Segment: Chemistry, Organic Chemistry, Biotech, Scientist, Pharmaceutical, Science

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