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Scientist: Molecular Cell Pharmacology

The Discovery Pharmacology department is looking for a highly motivated scientist to apply state-of-art technologies, particularly focused on molecular cellular pharmacology, developing tools to provide insight into biology/pharmacology of the molecules, to support pipeline projects related to our Immuno-oncology, Immunology and Oncology translational innovative platforms.

 

The selected candidates will provide technical expertise to develop cell-based assay using primary cells as well as tumor cell lines, analyze samples for various screening support activities, including but not limited to target identification/validation of target deconvolution for phenotypic screening and mode-of-action characterization. The candidate must manage cross-functional discovery project team.


Your role:

  • Develops innovative ideas, concepts and approaches to support screening activities for Immuno-Oncology and Immunology drug discovery
  • Keeps on the look-out, develops, and incorporates when needed new assay technologies or platforms to expedite the research during the pre-concept phase and improve data quality, reliability, and predictive value when moving to later stages of early clinical development
  • Design and support a variety of in vitro cell-based assays using primary immune cells including patient derived tumor cell lines
  • Significantly improves, changes or adapts existing methods and techniques. Implements cutting edge technologies and methodologies to investigate immune function.
  • Collaborate effectively with colleagues within the Immuno-Oncology/Immunology platform including our global counterpart group, as well as manage outsourcing activities as and when needed
  • Develops research solutions that require extensive analysis and detailed investigation.
  • Present scientific results to department including multidisciplinary teams at the project level

 

Who you are: 

  • Bachelor’s degree with 5 plus years, master’s degree with 3 plus years, or PhD degree in cell biology or related biology discipline with relevant experience in an industrial and/or academic setting strongly preferred
  • Bachelor’s degree with 3 plus years or master’s degree required
  • Hands on experiences in culture of primary immune cells and tumor cell lines, experience with advanced 3D tumor spheroid and co-culture studies preferred
  • Ability to conceptualize innovative ideas for immunotherapy and research assay tools
  • Familiarity with human and mouse flow based cytometric analysis with experience in high content and real time imaging experience.
  • Highly motivated, flexible and creative individual with a passion for drug discovery and development
  • Effective communication skills, and ability to explain methods and results to medicinal chemists and other scientists
  • Capable of working with autonomy and independently seek help from other scientists to solve problems and to learn new techniques.
  • Excellent interpersonal skills with the ability to interact effectively with people, internally and externally
  • Team oriented work ethic and ability to work in cross-functional teams
  • Outstanding presentation and interpersonal communication skills
Job Requisition ID:  188101
Location:  Billerica
Career Level:  C - Professional (1-3 years)
Working time model:  full-time


Nearest Major Market: Boston

Job Segment: Chemistry, Pharmaceutical, Immunology, Oncology, Pharmacology, Science, Healthcare

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