Senior Scientist - Medium Scale Oligo Synthesis

Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.  

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. 

Your Role:

EMD Serono in Billerica, MA is seeking a Senior Scientist – Medium Scale Oligo Synthesis to add to their Oligonucleotide Therapeutics Group (DDTech).

Responsibilities:

• Develop scalable, robust synthetic procedures; evaluate reaction scope, optimization, and critical process parameters like purification and desalting.
• Support scale‑up efforts from milligram to multi‑gram quantities; contribute to tech transfer to internal pilot‑scale labs or external partners.
• Utilize expertise in MM12 and Akta OP100 synthesizers and HPLC purification of oligonucleotides by anion-exchange and reverse-phase methods.
• Perform analytical methods such as UPLC, LC-MS, NMR and quality standards in oligonucleotide drug development.

• Work as part of a team with an excellent work ethic.  Present funding in team meetings.

• Maintain a well-documented laboratory notebook and follow the safe laboratory practices.
• Multi-task across several projects and manage time effectively to achieve results.

Who You Are:

Minimum Qualifications:

• PhD in Chemistry, Biochemistry, Chemical Engineering or other Science or Engineering discipline
• 5+ years of direct experience in oligonucleotide chemistry

Preferred Qualifications:

• Deep understanding of oligonucleotide and precursor synthesis, modification, purification, and conjugation mechanisms

• Strong knowledge of oligonucleotide synthesis, deprotection and purification techniques
• Knowledge and background in bioconjugation chemistry including dye, peptides and antibody-drug conjugates and related linkers
• Expertise in chromatography purification techniques and troubleshooting
• Strong laboratory skills and experience with analytical instrumentation such as NMR, HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data

Pay Range for this position: $111,100 - $166,600

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!