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PhD Project: Human intestinal advanced cell culture models for safety testing (all genders)


A career at our company is an ongoing journey of discovery: our 58,000 people are shaping how the world lives, works and plays through next generation advancements in Healthcare, Life Science and Electronics. For more than 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others.


United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.


Your role:

The primary research will focus on the validation / qualification of our hiPS colon organoids. This will include the understanding of what specific context of use(s) are the colon organoids suitable for, in relation to toxicity testing. 
Optimization and improvements to this model, including assessment of novel models, such as "inversion of organoids" and implementation of novel small intestine organoids (or other advanced cell systems) for toxicity testing.
A second major priority will be what to measure – which biomarkers are suitable or specific context-of-uses, how to incorporate imaging in to the assessment, can biosensors be used to monitor onset of toxicity?
Additional topics will include: i) multi-organ approaches; ii) inclusion of an immune organ (e.g., bone marrow, lymph node) or biologically relevant vascular system iii) initial assessment of animal related models in terms of preclinical safety testing.


Who you are:

1.    Master of Science in relevant scientific area (e.g., pharmacology, toxicology, biochemistry, biology)
2.    Experience with advanced cell culture models
3.    Excellent record with cell culture in general
4.    Understanding of drug related toxicity mechanisms and test systems
5.    Ability to work alone, alongside colleagues performing more routine toxicity assessments.



What we offer:  With us, there are always opportunities to break new ground. We empower you to fulfil your ambitions, and our diverse businesses offer various career moves to seek new horizons. We trust you with responsibility early on and support you to draw your own career map that is responsive to your aspirations and priorities in life. Join us and bring your curiosity to life!


Curious? Apply and find more information at https://jobs.vibrantm.com


Job Requisition ID:  223495
Location:  Darmstadt
Career Level:  A - Current Student
Working time model:  full-time

Careers during Covid-19
Thank you for visiting our careers website, we are always looking for curious minds to join our teams. We understand how much the world is being impacted by the Covid-19 crisis and we want to assure you that your safety is very important to us. To ensure that everyone’s health is protected, instead of a standard face-to-face interview, it is likely that you will be offered alternative digital interview options.

US Disclosure
The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law.  This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

North America Disclosure
The Company is committed to accessibility in its workplaces, including during the job application process. Applicants who may require accommodation during the application process should speak with our Candidate Services team at 844-655-6466 from 8:00am to 5:30pm ET Monday through Friday.

Job Segment: Biochemistry, Toxicology, Neurology, Oncology, Biology, Science, Healthcare

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