Principal Scientist (all genders) Structural Biology

Work Your Magic with us!  

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.  

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

Your Role

As a Principal Scientist (all genders) in the Structural Biology and Biophysics team, R&D Discovery, you will provide scientific leadership across interdisciplinary projects to elucidate structural mode of action and enable structure-based design with a focus on macromolecular complexes of antibodies, multispecifics, and molecular degraders. You will implement and broaden single-particle cryo-EM capabilities and drive experimental end-to-end strategies for structural enablement from protein and sample generation, data acquisition to structural model building. You will coordinate CRO and collaboration-partner activities for reagents and data generation and drive innovations in structural biology. You clearly explain and communicate scientific findings and proposals to cross-functional teams and stakeholders to influence informed and fast decision-making. You will mentor and develop junior scientists in structural biology and drug discovery, contributing to a high-performing, collaborative culture.

Who You Are

• PhD in Structural Biology or a related field with more than ten years of relevant experience (including biopharma/biotech) and a strong track record to design, execute and drive complex structural biology projects.
• Deep expertise in high-resolution structure determination by cryo-EM (sample generation, data collection and processing, structure refinement with industry-standard software).
• Experience working with antigen–antibody and protein degrader complexes, with a deep understanding of structure–function relationships.
• Preferably experience in protein crystallography and biophysical methods (e.g. HDX-MS, SAXS; Refeyn, FIDA, DSF); cloud-based/HPC data management and processing; LINUX scripting; AI/ML-based prediction of biomolecular structures.
• Effective collaborator and leader in multidisciplinary settings with excellent English communication; skilled in guiding and mentoring scientists, coordinating multi-site work, and managing CROs to balance project demands.
• Proven ability to convey complex data clearly to drive decisions; strong publication history or impactful drug discovery contributions (oncology/immunology/neuroscience favored); excellent problem-solving and experience introducing relevant new technologies. 

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!